Modern Medicine in Digital format

* Hair Disease, also known as hair diseases, is related to menkes disease and monilethrix, and has symptoms including skin manifestations, pruritus and exanthema. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways is Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include hair, ovary and skin, and related mouse phenotypes are pigmentation and muscle. Hair diseases are disorders primarily associated with the follicles of the hair.

* Hair Morphology 1, also known as hair morphology 1, hair thickness, is related to hypohidrotic ectodermal dysplasia autosomal recessive. An important gene associated with Hair Morphology 1 is EDAR (Ectodysplasin A Receptor), and among its related pathways/superpathways is Cytokine Signaling in Immune system. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2).

* Hair regeneration requires reactivating dormant hair follicle stem cells. Pharmacological induction of autophagy is sufficient to activate quiescent telogen hair follicles, initiating new anagen hair growth. Hair loss resulting from shortened anagen, lengthened telogen, and/or impeded anagen induction may thereby be rescued by activating autophagy. Quiescent (telogen) hair follicles can be stimulated to initiate anagen and hair growth by small molecules that activate autophagy, including the metabolites alpha-ketoglutarate (alpha-KG) and alpha-ketobutyrate (alpha-KB), and the prescription drugs rapamycin and metformin, which impinge on mTOR and AMPK signaling. Anagen can be pharmacologically activated in telogen skin when natural anagen-inducing signal(s) are absent has implications for the treatment of hair loss patients.

* Hair-skin care peptides. The recording plays each item for three minutes.
In order,
- Myristoyl Pentapeptide-17 antioxidant, eyelashes and eyebrows growth, stimulates production of keratin, the proteins that form eyebrows and lashes
- Decapeptide-3 anti-aging, anti-wrinkle, hair growth, reduces and prevents lines and wrinkles by actively generating new skin cells, involved in normal skin growth, healing and wound repair
- Astressin-B peptide for hair growth, hair regrowth, improves the sexual drive
- Decapeptide-10 anti-wrinkle, hair growth, skin brightening, reduces and prevents lines and wrinkles by actively generating new skin cells, refines texture glides effectively and lights up skin, helps strengthen hair while stimulating hair follicles to produce a strong hair shaft
- Copper Tripeptide-1 anti-aging, anti-wrinkle, anti-hair loss, helps strengthen hair while stimulating hair follicles to produce a strong hair shaft, helps blood circulation in the scalp and revitalizing hair follicles, reduces and prevents lines and wrinkles by actively generating new skin cells
- Octapeptide-2 anti-aging, anti-wrinkle, hair growth, increases cell growth and migration, promotes hair growth by activating the stem cells of hair follicles
- CRTH2 antagonist OC000459 airway inflammation, hair loss

* Halicin is a drug which acts as an inhibitor of the enzyme c-Jun N-terminal kinase (JNK). Halicin was identified by researchers at MIT in 2019 using an in silico deep learning approach, as a likely broad-spectrum antibiotic. This was subsequently verified by in vitro cell culture testing followed by in vivo tests in mice. It showed activity against drug-resistant strains of Clostridium difficile, Acinetobacter baumannii, and Mycobacterium tuberculosis, with an unusual mechanism of action involving the sequestration of iron inside the bacterial cells which thereby interferes with their ability to properly regulate the pH balance across the cell membrane. Since this is a different mode of action from most antibiotics, halicin retained activity against bacterial strains resistant to many commonly used drugs.

* Harmine is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. Harmine acts as a cell-type-specific regulator of PPARgamma expression. Administration of harmine to diabetic mice mimics the effects of PPARgamma ligands on adipocyte gene expression and insulin sensitivity. Unlike thiazolidinediones, however, harmine does not cause significant weight gain or hepatic lipid accumulation. Molecular studies indicate that harmine controls PPARgamma expression through inhibition of the Wnt signaling pathway. Harmine is currently the only known drug that induces proliferation (rapid mitosis and subsequent mass growth) of pancreatic alpha and beta cells in adult humans. These islet sub-cells are normally very resistant to growth stimulation in the adult stage of a human's life, as the cell mass plateaus at around age 10 and remains virtually unchanged from there on. Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a RIMA. Harmine selectively binds to MAO-A but does not inhibit the variant MAO-B. Monoamines include neurotransmitters (serotonin, dopamine), hormones (melatonin, epinephrine, norepinephrine). By slowing the breakdown of neurotransmitters, monoamine oxidase inhibitors (MAOIs) can help to replenish the body's supply of these chemicals, and many MAOIs are used as antidepressants. Harmine showed cytotoxicity against HL60 and K562 cell lines in cancer. This could explain the cytotoxic effect of P. harmala on these cells. Harmine was shown to promote differentiation of osteoblasts (bone-forming cells), and chondrocytes (cells in the cartilage). It was also shown to inhibit osteoclastogenesis (the formation of bone resorbing cells).

* HB107 Peptide is a derivative of Cecropin B, that has demonstrated efficacy in enhancing wound healing in both burn and incision animal models. HB107 has been evaluated for efficacy in a mouse incision model and for safety and efficacy in a pig burn wound model. The peptide was well tolerated in terms of safety both topically and in an IV acute toxicity mouse model with no adverse effects observed. HB107 not only demonstrated efficacy and safety, but due to being a relatively short synthetic peptide, costs significantly less to manufacture than the current approved therapies. Peptides of the innate immune system play a vital role in the protection and repair of almost all biological systems. Such peptides have been implicated in a range of activities associated with prevention of disease and modulation of innate immunity.

* HBB factor, beta globin (also referred to as, hemoglobin beta, or preferably haemoglobin subunit beta) is a globin protein, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans. HBB is involved in oxygen transport from the lung to the various peripheral tissues. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease, Heinz body anemias, and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria.

* Heart Disease, also known as congenital heart disease, is related to jervell and lange-nielsen syndrome and sick sinus syndrome 1, and has symptoms including hypoplastic left heart, angina pectoris and chest pain. An important gene associated with Heart Disease is GATA4 (GATA Binding Protein 4), and among its related pathways/superpathways are Vascular smooth muscle contraction and Human Embryonic Stem Cell Pluripotency. The drugs Ranolazine and Iloprost have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are cardiovascular system and growth/size/body region. A cardiovascular system disease that involves the heart.

* Heat Exhaustion Fluid Therapy includes a balance of electrolytes akin to Lactated Ringer's, recommended in restoration of the blood volume either in hypovolemia -blood loss due to trauma- or under severe dehydration. It is contraindicated in people with a pH > 7.5, in those with liver disease who are unable to metabolize lactate, or those with lactic acidosis. It is a mixture of sodium chloride, sodium lactate, potassium chloride, calcium chloride with mannitol added. The recording is not suitable for maintenance therapy (i.e., maintenance fluids) since the lactate is converted into bicarbonate, long-term use will cause patients to become alkalotic. Heat exhaustion is a severe form of heat illness. It is a medical emergency. Heat exhaustion is caused by the loss of water and electrolytes through sweating. The recording is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure.

* Heat Rash Mix plays the sound frequencies of salicylic acid, cetrimide, menthol, and acetone.

* Helenalin is a sesquiterpene lactone with a variety of observed effects including anti-inflammatory and antitumor activities. Helenalin has been shown to selectively inhibit the transcription factor NF-kappaB, which plays a key role in regulating immune response, through a unique mechanism. In vitro, it is also a potent, selective inhibitor of human telomerase —which may partially account for its antitumor effects—has anti-trypanosomal activity, and is toxic to Plasmodium falciparum. Animal and in vitro studies have also suggested that helenalin can reduce the growth of Staphylococcus aureus and reduce the severity of S. aureus infection.

* Hemarthrosis, also known as hemarthrosis involving pelvic region and thigh, is related to afibrinogenemia, congenital and factor x deficiency, and has symptoms including arthralgia, hemoptysis and metatarsalgia. An important gene associated with Hemarthrosis is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Bevacizumab and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and monocytes, and related phenotypes are cardiovascular system and homeostasis/metabolism. Hemarthrosis is a bleeding into joint spaces.

* Hematopoietic Cell Induction. This cocktail (Valproic acid (VPA), CHIR99021, and E616452), was initially discovered to induce neural stem or progenitor cell generation, which belongs to ectoderm. It is developmentally different direction from hematopoietic cell generation, which belongs to mesoderm. Ectoderm and mesoderm developmentally come from the same lineage and even mesectoderm committed progenitor cells are identified. Thus, it is speculated that the chemical cocktail used here might induce somatic cells into progenitor cells, which further develop into ectodermal neural cells or mesodermal hematopoietic cells individually under specific conditions. Hematopoietic stem/progenitor cells (HSPCs) hold great promise for treating hematopoietic system diseases. These expanding and advanced reprogramming strategies might yield inexhaustible hematopoietic cells for cell therapy.

* Hemorrhage, Intracerebral, also known as hemorrhage, intracerebral, susceptibility to, is related to cerebral hemorrhage and cerebral amyloid angiopathy, cst3-related, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Neuroscience and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and eye, and related phenotypes are cardiovascular system and growth/size/body region. A stroke is a medical emergency. There are two types - ischemic and hemorrhagic. Hemorrhagic stroke is the less common type. It happens when a blood vessel breaks and bleeds into the brain.

* Hemosiderosis, also known as haemosiderosis, is related to aceruloplasminemia and atransferrinemia. An important gene associated with Hemosiderosis is CP (Ceruloplasmin), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. The drugs Iron and Deferasirox have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and bone, and related phenotypes are hematopoietic system and liver/biliary system. An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

* Hemostasis peptides, targets the cascade of events that occur when blood is present outside the blood vessels such as in Peripheral Arterial Disease or Venous Insufficiency. Each product plays for three minutes eighteen seconds.
In playing order,
- RPI peptide - Prenyl Protein Inhibitor -anti-inflammatory
- Hannahpep peptide - fibrinolytic
- Vasoactive intestinal polypeptide (VIP) - vasodilator
- MMP-9 Peptide Inhibitor - metalloproteinase 9 inhibitor
- Vasoactive intestinal polypeptide (VIP) - vasodilator
- Fibrinogen Binding Inhibitor Peptide - inhibit formation of blood clots
- Cilostazol (drug) - intermitent claudication, arterial vasodilator, platelet aggregation inhibitor
- AICA-Ribonucleotide peptide (AICAR) - ischemic injury, diabetes

* Henoch-Schoenlein Purpura, also known as henoch-schonlein purpura, is related to amebiasis and arteries, anomalies of. An important gene associated with Henoch-Schoenlein Purpura is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Selenium Micronutrient Network. The drugs Prednisone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related phenotypes are nausea and vomiting and arthralgia. A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection.

* Hernia hiatal gene therapy, plays for 5m each frequency of some associated genes.
In order, ABCB1, CYP3A4 and CYP2C19.

* Herpes zoster gene therapy, includes antiviral, symptom management and postherpetic neuralgia agents. Each item plays for 2m. In playing order, Botox, Fasinumab, Alefacept, Immune system normalization frequency, Astaxanthin, Substance P, NGF precursor, Opipramol, Prednisone, Docosanol, Famciclovir, Capsaicin, Foscarnet, Caladryl, Vidarabine, Tromantadine, Taribavirin, Cidovir, Lidocaine, Morxydine, Sodium Bromide.

* Hexamine is used for the treatment of urinary tract infection. It decomposes at an acidic pH to form formaldehyde and ammonia, and the formaldehyde is bactericidal; the mandelic acid adds to this effect. Hexamine was first introduced into the medical setting in 1899 as a urinary antiseptic. However, it was only used in cases of acidic urine, whereas boric acid was used to treat urinary tract infections with alkaline urine. In an alkaline environment, hexamine was found to be almost completely inactive. Its use had temporarily been reduced in the late 1990s, due to adverse effects, particularly chemically-induced hemorrhagic cystitis in overdose, but its use has now been re-approved because of the prevalence of antibiotic resistance to more commonly used drugs. This drug is particularly suitable for long-term prophylactic treatment of urinary tract infection, because bacteria do not develop resistance to formaldehyde. It should not be used in the presence of chronic kidney disease. Hexamine is successfully used for treatment of excessive sweating and concomitant odor.

* Hexarelin peptide is an effective and cardioprotective synthetic peptide growth hormone secretagogue that can bring about growth hormone secretion. Effects that may come about with this include higher levels of mitosis, bone mineral density, muscle mass, fat loss, elasticity and connective tissues.

* HGH (176-191) peptide exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.

* HGH (177-191) peptide reduces body fat in obese animals but, enhances fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted Growth Hormone effect. Recent research has shown this fragment to be an extremely potent and effective fat burner. Actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.

* HIF1A-EPAS1 Factors. The balance between hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha activity in keratinocytes controls skin perfusion, systemic thermoregulation, and systemic blood pressure by nitric oxide-dependent mechanisms. Furthermore, the skin accumulates sodium (Na) which generates a barrier to promote immunological host defense. Immune cells control skin Na metabolism and the clearance of Na via the lymphatic system. Reduced lymphatic clearance increases blood pressure.

* Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin, hirudin binds to and inhibits only the activated thrombin, with a specific activity on fibrinogen. Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e., it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins, and can also act on complexed thrombin.

* HLA class I histocompatibility antigen, B-27 alpha chain precursor variations affecting this gene are associated with a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints.

* hLF 1–11 is a cationic peptide fragment comprising amino-terminal amino acids 1–11 of human lactoferricin to treat bacteraemia and fungal infections in immuno-compromised haematopoetic stem cell transplant recipients.

* Honokiol is a pleiotropic compound, meaning it is able to act on the body through a number of pathways. This diversity of interaction makes it a viable therapy for a number of conditions in the central nervous system, cardiovascular system, and gastrointestinal system. It has been shown to have antitumorigenic, anti-inflammatory, and antioxidant effects as well.

* HPP593 aims to recharge tired cells, giving mitochondrial disease patients new hope of a disease-specific treatment. Mitochondria are little power factories inside almost every cell in the body; they provide each cell with the energy it needs to function. Mitochondria are unique because they contain their own genome, completely separate from the entire nuclear genome you usually think about. Mutations in mitochondrial genes can disrupt the ATP creation pathway, stunting mitochondria’s ability to create energy. Dysfunctional mitochondria leave cells fatigued. Primary mitochondrial myopathies (PMMs) are a group of rare, often life-threatening, mitochondrial diseases where genetic mutations in the mitochondria cause muscle dysfunction and weakness, among other problems. There are at least 50 different syndromes under the category of PMMs, a lot of syndromes overlap, and, thanks to mitochondrial sequencing, we now know they are caused by the same genetic lesion.

* HSP-10 (Heat Shock Protein) factor helps monitor and organise protein interactions in the body, and responds to environmental stresses, such as exercise and infection, by increasing its production inside cells. Excessive amounts of HSP10 inside mitochondria -'organs' that act as energy generators in cells- can halt the body's aging process by preserving muscle strength. Age-related loss of skeletal muscle mass is not inevitable and this could have considerable implications for the future health care of the elderly. Between the ages of 50 and 70 we lose approximately 25-30% of our muscle. Falls -a major cause of injury and death in people over the age of 65 -are often the direct result of loss of mobility and weakened skeletal muscle.

* HSP-27 factor (Heat Shock Protein). Our peripheral nerves connect our brain and spinal cord to the rest of our body, controlling all volitional muscle movements. However, they are fragile and very easily damaged. Peripheral nerves can regenerate after injury, and if the site of damage is close to the muscle controlled by the damaged nerve, full muscle function is frequently restored. However, if the site of damage is far from the muscle controlled by the damaged nerve, recovery of muscle function is minimal. Hsp27 promotes peripheral nerve regeneration.

* HU-211 is a synthetic terpene-based cannabinoid devoid of central cannabinoid (CB1) and peripheral cannabinoid (CB2) agonist activity, thus lacking the psychomotor responses characteristic of delta9-THC. HU-211 does exhibit the neuroprotective, antioxidant properties of other related compounds like cannabidiol. HU-211 also has anti-inflammatory properties derived through inhibition of NF-kappaB and the resulting decreases in cytokines such as TNFalfa and interleukin-6.

* Human prestin factor is a protein that is critical to sensitive hearing in mammals. Prestin is the motor protein of the outer hair cells of the inner ear of the mammalian cochlea. It is highly expressed in the lateral plasma membrane of outer hair cells, the region where electromotility occurs. The expression pattern correlates with the appearance of outer hair cell electromotility.

* Human SCN4A (Voltage-gated sodium channel 4 alpha) factor provides instructions for making a critical part (the alpha subunit) of sodium channels that are abundant in muscles used for movement (skeletal muscles). For the body to move normally, these muscles must tense (contract) and relax in a coordinated way. One of the changes that helps trigger muscle contractions is the flow of positively charged atoms (ions), including sodium, into muscle cells. Channels made with the SCN4A protein control the flow of sodium ions into these cells.

* Human vomeronasal stimulation targets type 1 receptors of the vomeronasal organ. These receptors are thought to be responsible for pheromone detection. The frequencies for the receptors VN1R1, VN1R2, VN1R3, VN1R4, and VN1R5 are included. Some of them appear to be functionless. (See notes below for pseudogene rationale)

* Humanin HN peptide and derivatives suppress neuronal cell death induced by the three different types (mutant amyloid precursor protein, presenilin 1, and presenilin 2) of familial Alzheimer’s Disease genes and by A beta. In addition to Alzheimer’s disease, humanin has other neuroprotective effects against models of Huntington’s disease, prion disease, and stroke. Beyond the possible neuroprotective effects, humanin protects against oxidative stress, atherosclerotic plaque formation, and heart attack. Metabolic effects have also been demonstrated and humanin helps improve survival of pancreatic beta-cells, which may help with type 1 diabetes, and increases insulin sensitivity, which may help with type 2 diabetes.

* Humatrope is a polypeptide hormone of rDNA origin. It is used to stimulate linear growth in pediatric patients who lack adequate normal human growth hormone.

* Humpback-whale myoglobin factor serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. More powerful than human myoglobin, may enhance divers' performance.

* Humpback-whale prestin is a type of biological sonar to find their way about by making high-pitched calls and timing the rebounding echoes. It is a transmembrane protein (10-12 transmembrane domains) with the ability to convert a change in membrane potential into a mechanical force. It is a "direct voltage-to-force converter" and plays a crucial role in sound amplification in various organisms and thus play an important part in an organism's ability to sense sound waves (sensory perception of sound), echolocation or ultrasonic hearing.

* Hydrarthrosis is related to intermittent hydrarthrosis and gestational diabetes, and has symptoms including arthralgia, metatarsalgia and joint swelling. An important gene associated with Hydrarthrosis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways are Aquaporin-mediated transport and SIDS Susceptibility Pathways. Affiliated tissues include bone, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism. An effusion of watery liquid into the cavity of a joint.

* Hydrocortamate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects.

* Hydroxychloroquine is used to treat systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever, and certain types of malaria. It is considered the first line treatment for systemic lupus erythematosus. Certain types of malaria, resistant strains, and complicated cases require different or additional medication. It is widely used to treat primary Sjögren syndrome, but has not been shown to be effective. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Hydroxychloroquine is being studied as an experimental treatment for coronavirus disease 2019 (COVID-19).

* Hydroxycitric acid (HCA), a derivative of citric acid found in some tropical fruits, is a competitive inhibitor of ATP citrate lyase, which converts citrate into oxaloacetate and acetyl CoA. The reverse of this conversion is a step in the citric acid cycle. Laboratory and animal studies of HCA have produced results that indicate a potential for modulation of lipid metabolism. Researchers at the University of Houston reported hydroxycitrate is capable of dissolving calcium oxalate crystals, a component of human kidney stones. This is an unusual effect because it is rare for a crystal to dissolve while in a supersaturated growth solution.

* Hydroxypyridinone is a molecule used in a type of therapy known as chelation, in which specific molecules are used to remove heavy metals like mercury or, in this case, uranium from the bloodstream. This particular chelating agent removed roughly 80 percent of the residual uranium in the kidneys of exposed mice, while 50 percent of the residual radioactive material was extracted from the animals’ bones, with minor adverse effects.

* Hydroxytyrosol is a type of phenolic phytochemical with antioxidant properties found in olive leaf and olive oil. Hydroxytyrosol has demonstrated an exceptional capacity for neutralizing free radicals and can be a powerful tool in the fight against oxidative stress and chronic disease. In a study, Hydroxytyrosol has been shown to double vitamin C levels in blood.

* Hypercholesterolemia, Familial, also known as familial hypercholesterolemia, is related to hypercholesterolemia, familial, autosomal recessive and hyperlipidemia, familial combined, and has symptoms including corneal arcus, xanthelasma and hypercholesterolemia. An important gene associated with Hypercholesterolemia, Familial is LDLR (Low Density Lipoprotein Receptor), and among its related pathways are SREBF and miR33 in cholesterol and lipid homeostasis and Folate Metabolism. The drugs ezetimibe and atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and liver, and related mouse phenotypes are Increased LDL uptake and Decreased free cholesterol. A condition characterized by very high levels of cholesterol in the blood.

* Hyperfibrinolysis gene therapy, addresses acquired disturbance of fibrinolysis (Hyperfibrinolysis). It may occur after trauma or in patients who suffer from an overwhelming activation of tissue factor. Fibrinolysis is a process that prevents blood clots from growing and becoming problematic. The recording includes frequencies for fibrinolytics, fibrinolysis gene factor activators and inhibitors, and plasmin inactivators. Each item plays for three minutes unless stated otherwise.
The products used in playing order, SERPINF2, PLAU, CPB2, SERPINB1, SERPINE1, PLAT, A2M, Stanozol, Tranexamic acid, 4-Aminomethylbenzoic acid (2m), Aminocaproic acid (2m).

* Hyperforin is a phytochemical believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort. Other medicinal properties of hyperforin include anti-inflammatory and antibiotic effects. As an anti-inflammatory agent, hyperforin inhibits the cyclooxygenase, COX-1, and the lipoxygenase, 5-LO. The anti-inflammatory effect of hyperforin is 3 – 18 times that of aspirin.

* Hyperglycemia is related to diabetes mellitus, permanent neonatal and diabetes mellitus, transient neonatal, 3, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Hyperglycemia is INS (Insulin), and among its related pathways/superpathways are Developmental Biology and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Glipizide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region. Hyperglycemia, or high blood sugar is a condition in which an excessive amount of glucose circulates in the blood plasma.

* Hyperinsulinemic Hypoglycemia, also known as islet cell hyperplasia, is related to hyperinsulinemic hypoglycemia, familial, 3 and hyperinsulinemic hypoglycemia, familial, 7. An important gene associated with Hyperinsulinemic Hypoglycemia is KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11), and among its related pathways/superpathways are Aldosterone synthesis and secretion and MAPK signaling pathway. The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, pancreatic islet and brain, and related phenotypes are growth/size/body region and endocrine/exocrine gland. A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.

* Hyperinsulinism, also known as hyperinsulinemia, is related to hyperinsulinemic hypoglycemia, familial, 6 and alstrom syndrome. An important gene associated with Hyperinsulinism is HNF4A (Hepatocyte Nuclear Factor 4 Alpha), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Aldosterone synthesis and secretion. The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and liver, and related phenotypes are Reduced mammosphere formation and growth/size/body region. An above normal level of insulin in the blood of a person.

* Hypersensitivity Vasculitis, also known as cutaneous small vessel vasculitis, is related to systemic lupus erythematosus and allergic cutaneous vasculitis, and has symptoms including cutis marmorata, urticaria and subcutaneous hemorrhage. An important gene associated with Hypersensitivity Vasculitis is CD79A (CD79a Molecule), and among its related pathways are Immune response Lectin induced complement pathway and Creation of C4 and C2 activators. Affiliated tissues include skin, neutrophil and testes, and related mouse phenotype immune system. An inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura.

* Hypertension, Essential, also known as essential hypertension, is related to arteries, anomalies of and coronary artery anomaly, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Corticotropin-releasing hormone signaling pathway. The drugs Adcirca and Adempas have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure. A hypertension with no known cause. It is the most common type of hypertension (high blood pressure).

* Hypertriglyceridemia, also known as hypertriglyceridemia, familial, is related to hyperlipoproteinemia type iv and lipodystrophy, familial partial, type 2, and has symptoms including precocious atherosclerosis, abnormal glucose tolerance and atheroeruptive xanthoma. An important gene associated with Hypertriglyceridemia is LIPI (Lipase I), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Metformin and Saxagliptin have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and endothelial, and related phenotypes are Decreased free cholesterol and Increased LDL uptake. Hypertriglyceridemia denotes high blood levels of triglycerides.

* Hypertrophic Cardiomyopathy, also known as cardiomyopathy, hypertrophic, familial, is related to cardiomyopathy, familial hypertrophic, 1 and cardiomyopathy, familial hypertrophic, 6. An important gene associated with Hypertrophic Cardiomyopathy is TNNI3 (Troponin I3, Cardiac Type), and among its related pathways/superpathways are Hypertrophic cardiomyopathy (HCM) and Aldosterone synthesis and secretion. The drugs Spironolactone and Ranolazine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are Increased shRNA abundance and cardiovascular system. A condition in which a portion of the heart becomes thickened without an obvious cause. This results in the heart being less able to pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. Complications include heart failure, an irregular heartbeat, and sudden cardiac death.

* Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 3 and hyperinsulinemic hypoglycemia, familial, 6, and has symptoms including sugar craving An important gene associated with Hypoglycemia is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Pramlintide and Diazoxide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, brain and testes, and related phenotypes are no effect and shRNA abundance <= 50%. Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels.

* Hypoglycemic Coma is related to hemangiopericytoma, malignant and acyl-coa dehydrogenase, medium-chain, deficiency of. An important gene associated with Hypoglycemic Coma is INS (Insulin), and among its related pathways/superpathways are TGF-Beta Pathway and PI3K-Akt signaling pathway. The drugs Etanercept and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver, and related phenotypes are muscle and reproductive system. A severe consequence of low blood sugar levels.

* Hypothalamic Disease, also known as hypothalamic diseases, is related to rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome and anophthalmia cleft lip palate hypothalamic disorder. An important gene associated with Hypothalamic Disease is CRH (Corticotropin Releasing Hormone), and among its related pathways are Growth hormone receptor signaling and Corticotropin-releasing hormone. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are endocrine/exocrine gland and immune system. A condition in which the hypothalamus is not working properly.

* Hypotonia is related to hypotonia-speech impairment-severe cognitive delay syndrome and hypotonia, infantile, with psychomotor retardation. An important gene associated with Hypotonia is NALCN (Sodium Leak Channel, Non-Selective), and among its related pathways/superpathways are Post-translational modification- synthesis of GPI-anchored proteins and Glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The drugs Naproxen and Quinine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and skeletal muscle. Hypotonia is a medical term used to describe decreased muscle tone. Normally, even when relaxed, muscles have a very small amount of contraction that gives them a springy feel and provides some resistance to passive movement. It is not the same as muscle weakness, although the two conditions can co-exist.

* Hypotrichosis is related to hypotrichosis 6 and hypotrichosis 7. An important gene associated with Hypotrichosis is MUHH2 (Hypotrichosis, Hereditary, Marie Unna Type, 2), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Minoxidil and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and testes, and related phenotype is integument. A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.

* Hypoxia is related to methemoglobinemia and renal cell carcinoma, and has symptoms including anoxemia, cachexia and cyanosis. An important gene associated with Hypoxia is HIF1A (Hypoxia Inducible Factor 1 Alpha Subunit), and among its related pathways are Transcription Ligand-dependent activation of the ESR1/SP pathway and Notch-mediated HES/HEY network. Affiliated tissues include endothelial, lung and brain, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland. Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or region of the body (tissue hypoxia) is deprived of adequate oxygen supply. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.