Modern Medicine in Digital format

* P-113 is a peptide containing 12 of the 24 amino acid residues of the parent molecule, histatin 5, retains full antibacterial activity and has a good spectrum of activity in vitro against prominent pathogens such as P. aeruginosa, S. aureus and H. influenzae.

* P7C3-A20 is a derivative of P7C3, a proneurogenic, neuroprotective agent. P7C3A20 is a more potent fluorinated analogue of P7C3 (up to ten times stronger). P7C3 acts in preserving new nerve cells, using medicinal chemisty techniques and cultured cells. Results showed that active variants of P7C3 protected cultured cells from doxorubicin-mediated toxicity selectively, as demonstrated by three findings: 1) doxorubicin reduced intracellular Nicotinamide Adenine Dinucleotide (NAD) levels, most likely by activation of PARP; 2) active variants of P7C3 protected cultured cells from dox:tox presumably by stimulating a rebound in intracellular levels of NAD; and 3) active P7C3 variants enhanced activity of purified NAMPT enzyme. The dox:tox protective effect is directly connected to the ability of P7C3 to enhance the salvage pathway by which nicotinamide is converted to NAD. Their findings are supported by earlier reports that programmed expression of NAMPT enzyme protected mammalian cells from genotoxic stress as well as extending life span of budding yeast.

* PAC-113 is a synthetic 12-mer peptide derived from histatin 3 and histatin 5 for oral candidiasis.

* PACAP 6-38 is a potent and competitive pituitary adenylate cyclase-activating polypeptide receptor, PAC1 antagonist. Inhibits PACAP(1-27)-induced stimulation of adenylate cyclase. It has antitumor activity in vivo.

* PACAP-Related Peptide (PRP) is a PAC1, VPAC1 and VPAC2 receptor antagonist. It is an excitatory neuropeptide. Induces Ca2+mobilization. It plays a role in hypertension and stress responses.

* Paeoniflorin is a novel heat shock protein-inducing compound, is mediated by the activation of heat shock transcription factor 1 (HSF1), which has antiallergic, anti-obesity, anti-inflammatory and immunoregulatory effects. Paeoniflorin can activate PI3K/Akt signaling pathway to protect from PC12 cell induced injury, it protects thymocytes against irradiation-induced cell damage by scavenging ROS and attenuating the activation of the mitogen-activated protein kinases. Paeoniflorin thermotolerance induction may also help in heat stress.

* Palmoplantar Keratosis, also known as palmoplantar keratoderma, is related to keratoderma, palmoplantar, with deafness and palmoplantar keratoderma, epidermolytic. An important gene associated with Palmoplantar Keratosis is CTSC (Cathepsin C), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Etanercept and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is integument. A keratosis characterized by abnormal thickening of the palms and the soles.

* Pancreas Disease, also known as abnormality of the pancreas, is related to endocrine pancreas disease and functioning pituitary adenoma, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Pancreas Disease is INS (Insulin), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Pancrelipase and Secretin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related phenotypes are homeostasis/metabolism and adipose tissue. An endocrine system disease that is located in the pancreas.

* Pancreatic Polypeptide regulates pancreatic and gastrointestinal functions.

* Pandemic Viral Infection presents products related to viral epidemics.
3m
RNA Polymerase inhibitor - Favipiravir
NS3/4A Protease inhibitor - Simeprevir
RNA Synthesis inhibitor - Tarbavirin
3m
Reverse Transcriptase inhibitor - Racivir
Reverse Transcriptase inhibitor - Efavirenz
Reverse Transcriptase inhibitor - Tenofovir
3m
Entry inhibitor - VIR-576 peptide
NS5B inhibitor - Sofusbuvir
RSV Prevention - Palivizumab
3m
Antiviral - Galidesivir
Immunomodulator - Alfacon-1
Monoclonal Antibody - Bavituximab
3m
Antiviral - Remdesivir
Antiretroviral Protease inhibitor - Saquinavir
Improved Saquinavir absorption - Omeprazole
3m
Antiretroviral - Lopinavir
Antiretroviral - Ritonavir
Protease inhibitor - Indinavir
3m
Antibiotic Immunosuppresive - Myriocin
Immunosuppressive - Mycophenolic acid
Immunosuppressive - Sirolimus

* Papulacandin-B inhibits the growth of yeasts. It is a polypeptide antibiotic containing a long-chain fatty acid that inhibits the synthesis of glucan in spheroplasts, and glucan synthesis during cell-wall synthesis, and thus causing lysis of cells by osmotic rupture.

* Paranasal Sinus Disease, also known as paranasal sinus diseases, is related to myoglobinuria recurrent and dahlberg borer newcomer syndrome. An important gene associated with Paranasal Sinus Disease is IL5 (Interleukin 5), and among its related pathways are Inflammatory Response Pathway and IL4-mediated signaling events. Affiliated tissues include eye, bone and t cells, and related mouse phenotypes are craniofacial and neoplasm.

* Paranoid Schizophrenia, also known as chronic paranoid schizophrenia, is related to ulcerative colitis and personality disorder. An important gene associated with Paranoid Schizophrenia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Amphetamine addiction and Serotonergic synapse. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and nervous system. A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening.

* Parkinson Disease 1, also known as autosomal dominant parkinson disease 1, is related to kufor-rakeb syndrome and parkinson disease, late-onset, and has symptoms including urinary urgency, dysarthria and mental deterioration. An important gene associated with Parkinson Disease 1 is SNCA (Synuclein Alpha), and among its related pathways are Proteolysis_Putative ubiquitin pathway and Alpha-synuclein signaling. Affiliated tissues include brain, subthalamic nucleus and cortex, and related mouse phenotypes are taste/olfaction and cellular. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia.

* Parkinson Disease, Late-Onset, also known as parkinson disease, is related to parkinson disease 1 and parkinson disease 6, early onset, and has symptoms including hallucinations, dysautonomia and urinary urgency. An important gene associated with Parkinson Disease, Late-Onset is GBA (Glucosylceramidase Beta), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinsons Disease Pathway. The drugs biperiden and carbidopa have been mentioned in the context of this disorder. Affiliated tissues include brain, subthalamic nucleus and testes, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia.

* Paronychia (update), also known as paronychia inflammation, is related to candidal paronychia and neuropathy, hereditary sensory and autonomic, type iia. An important gene associated with Paronychia is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Irinotecan and Phylloquinone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are Decreased viability and Decreased viability. A nail disease characterized by often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail.

* Paronychia, also known as paronychia inflammation, is related to aggressive digital papillary adenocarcinoma and adenocarcinoma. An important gene associated with Paronychia is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are ERK Signaling and HIV Life Cycle. The drugs Fluorouracil and Cetuximab have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and colon, and related phenotypes are Decreased viability and Decreased viability. A nail disease that is an often-tender bacterial or fungal infection of the hand or foot where the nail and skin meet at the side or the base of a finger or toenail.

* Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are AGE/RAGE pathway and LPA receptor mediated events. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism. The inflammation of one or both parotid glands, the major salivary glands located on either side of the face, in humans.

* Paroxetine hydrochloride is the hydrochloride salt of paroxetine. It is an antidepressant drug. It has a role as an antidepressant, an anxiolytic drug, a hepatotoxic agent, a P450 inhibitor and a serotonin uptake inhibitor. It contains a paroxetinium(1+). Paroxetine hydrochloride has not been previously implicated in the context of hyperglycemia or diabetes. Paroxetine reduced hyperglycemia-induced mitochondrial ROS formation, mitochondrial protein oxidation, and mitochondrial and nuclear DNA damage, without interfering with mitochondrial electron transport or cellular bioenergetics. The ability of paroxetine to improve hyperglycemic endothelial cell injury was unique among serotonin reuptake blockers and can be attributed to its antioxidant effect, which primarily resides within its sesamol moiety. Paroxetine maintained the ability of vascular rings to respond to the endothelium-dependent relaxant acetylcholine, both during in vitro hyperglycemia and ex vivo, in a rat model of streptozotocin-induced diabetes. Thus, the current work identifies a novel pharmacological action of paroxetine as a protector of endothelial cells against hyperglycemic injury and raises the potential of repurposing of this drug for the experimental therapy of diabetic cardiovascular complications.

* Patellofemoral Pain Syndrome is related to glandular tularemia and hypotropia, and has symptoms including arthralgia, metatarsalgia and joint laxity. An important gene associated with Patellofemoral Pain Syndrome is PRF1 (Perforin 1), and among its related pathways are Estrogen signaling pathway and Downstream signaling in naive CD8+ T cells. Affiliated tissues include bone and testes, and related mouse phenotypes are hematopoietic system and immune system. A syndrome characterized by knee pain ranging from severe to mild discomfort seemingly originating from the contact of the posterior surface of the patella (back of the kneecap) with the femur (thigh bone).

* Pathological Gambling, also known as compulsive gambling, is related to antisocial personality disorder and cocaine dependence. It is an impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life. Many people enjoy gambling, whether it's betting on a horse or playing poker on the internet. Most people who gamble don't have a problem, but some lose control of their gambling. Signs of problem gambling include always thinking about gambling lying about gambling spending work or family time gambling feeling bad after you gamble, but not quitting gambling with money you need for other things.

* PBI-4050 is an oral compound designed to prevent inflammation and tissue scarring in several organs, including the lungs, kidneys, liver, heart and pancreas. PBI-4050 targets a new antifibrotic pathway involving two receptors that play opposite roles in fibrosis development, GPR40 has a protective effect while GPR84 has a damaging effect. PBI-4050 binds to both receptors, but while it activates GPR40, it suppresses the activity of GPR84, which is potentially beneficial in treating fibrosis. The therapy also showed benefits in type 2 diabetes patients with metabolic syndrome, and patients with Alström syndrome.Pulmonary fibrosis, which is a hardening of the tissues of the lung that prevents its proper functioning is one of the long-term effects that Covid-19 could leave.

* PEA (palmitoylethanolamide) is a fatty acid amide molecule which has been shown to have anti-inflammatory properties, especially relating to neuropathic pain, and modulate immune system responses. It can be found in plant, human, and animal tissues. When the body experiences pain or inflammation, levels of endogenous PEA increase. PEA works directly to reduce inflammation by inhibiting inflammatory cytokines. Cytokines are proteins that function as intracellular messengers. Specifically, PEA inhibits the secretion of a cytokine called tumor necrosis factor alpha (TNF alpha). Perhaps the biggest effect on inflammation which PEA exerts is over interleukins, a type of cytokine that is a protein which helps cells communicate. Like TNF alpha, interleukins are secreted during the inflammation process, and they are part of the immunological system. PEA indirectly activates the endocannabinoid system within the body. The ECS (endocannabinoid system) contains fat based neurotransmitters and proteins that bind with cannabinoid receptors in the brain and peripheral nervous system. The current understanding of the ECS is that it is involved in processes such as pain-sensation, immune system activity, fertility, pre/post-natal development, mood, and memory. PEA seemed to bolster the effect of pharmaceutical analgesics, such as oxycodone, in patients with sciatic and back pain, vertebral stenosis, and hernia when previous treatment with analgesics alone did not offer pain relief. PEA also reduced arthritis, back pain after surgery (failed back surgery syndrome), fibromyalgia and, endometriosis. Beside immunotherapeutic benefits, PEA improves brain recovery after injury or disease and, offers mood, immune, and eye support without adverse side effects.

* Peginterferon alpha-2b acts as a multifunctional immunoregulatory cytokine by transcribing several genes, including interleukin 4 (IL4). This cytokine is responsible for inducing T helper cells to become type 2 helper T cells. This ultimately results in the stimulation of B cells to proliferate and increase their antibody production. This ultimately allows for an immune response, as the B cells will help to signal the immune system that a foreign antigen is present. Another major mechanism of type I interferon alpha (IFNalfa) is to stimulate apoptosis in malignant cell lines. One of the major mechanisms of PEG-interferon alpha-2b utilizes the JAK-STAT signaling pathway. Pegylated interferon alfa-2b is a treatment for hepatitis C and melanoma with nodal involvement after surgical resection.

* Pegylated interferon alfa-2a is an antiviral drug; it has a dual mode of action - both antiviral and on the immune system. This drug is for the treatment of chronic hepatitis C (including patients with HIV co-infection, cirrhosis, 'normal' levels of ALT) and for the treatment of chronic hepatitis B. Peginterferon alfa-2a is a long acting interferon. Interferons are proteins released in the body in response to viral infections. Interferons are important for fighting viruses in the body, for regulating reproduction of cells, and for regulating the immune system.

* Pegylated mechano growth factor PEG MGF peptide, is a pegylated splice variant of the IGF-1 gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle.

* Pembrolizumab is a drug that targets the programmed cell death 1 (PD-1) receptor. This monoclonal antibody is intended for use in treating metastatic melanoma.

* Pentosan polysulfate sodium is a disease modifying osteoarthritis drug (DMAOD) also prescribed for interstitial cystitis.

* Pentoxifylline primary use in medicine is in treating the symptoms of intermittent claudication resulting from peripheral artery disease. Other indications for which the literature supports its use in include: multi-infarct dementia, Peyronie's disease, sarcoidosis, peripheral neuropathy, sickle cell disease, alcoholic and non-alcoholic steatohepatitis, endometriosis, and radiation-induced fibrosis. Pentoxyphylline is also used to prevent renal toxicity in cases of alcoholic hepatitis, and sperm motility after ejaculation.

* Pep-E peptide blocks the binding of IgE to the cell-anchored receptor and efficiently prevents histamine release from mast cells.

* Pepstatin-A peptide is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibition is highly selective and does not affect thiol proteases, neutral proteases, or serine proteases.

* Peptic Ulcer Disease, also known as peptic ulcer, is related to active peptic ulcer disease and peptic ulcer perforation, and has symptoms including gastrointestinal gas, signs and symptoms, digestive and nausea and vomiting. An important gene associated with Peptic Ulcer Disease is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Antiulcer drugs and Cytokine Signaling in Immune system. The drugs Aspirin and Pantoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney, and related phenotypes are digestive/alimentary and endocrine/exocrine gland. A break in the lining of the stomach, first part of the small intestine or occasionally the lower esophagus.

* Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to peptic ulcer disease and diclofenac allergy. An important gene associated with Peptic Ulcer Perforation is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are L1CAM interactions and Salivary secretion. The drugs Clopidogrel and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and neutrophil, and related phenotypes are Decreased caspase 3/7 activity and digestive/alimentary. Penetration of a Peptic Ulcer through the wall of duodenum or stomach allowing the leakage of luminal contents into the peritoneal cavity.

* Peptide 6 enhances neurogenesis in a mouse model of mild to moderate Traumatic Brain Injury. Chronic administration of this molecule resulted in recovery of dendritic density and synaptic loss and activation of the traditional tri-synaptic memory pathway in the hippocampus of injured mice. This also resulted in improvement in memory on behavioral testing. The fact that this molecule is neurogenic and is given peripherally and non-invasively demonstrates its potential in hippocampal regeneration in the post-traumatic brain. Available data further emphasizes the role of neurotrophic factor supplementation in TBI and makes a strong case for neurotrophic factor-based novel therapies for the injured hippocampus.

* Peptide-T is used for cognitive problems, such as memory loss, and trouble with speaking.

* Perfluorodecalin is a fluorocarbon, a derivative of decalin in which all of the hydrogen atoms are replaced by fluorine atoms. It is chemically and biologically inert and stable up to 400 °C. Several applications make use of its ability to carry and release oxygen and, it is not ozone depleting as it contains no chlorine or bromine atoms. Fluoroalkanes carry oxygen so well that mammals, including humans, can survive breathing liquid PFC solution, called liquid breathing. PFCs in solution act as an intravascular oxygen carrier to temporarily augment oxygen delivery to tissues. In theory, liquid breathing could assist in the treatment of patients with severe pulmonary or cardiac trauma, especially in pediatric cases. Liquid breathing has also been proposed for use in deep diving and space travel. Perfluorocarbon-based oxygen carriers (PFBOC) are currently a type of 'oxygen-carrying' blood substitute being pursued along with hemoglobin-based oxygen carriers (HBOC). Oxygen therapeutics, even if widely available, would not eliminate the use of human blood, which performs various functions besides oxygen transport. However oxygen therapeutics have major advantages over human blood in various situations, especially trauma. Due to its gas-carrying capacity, perfluorodecalin has been used to enhance oxygen delivery during cell culture. The physiological impact of mounting the specimen in perfluorodecalin is also minimal compared to water. Perfluorodecalin was an ingredient in Fluosol, an artificial blood product developed by Green Cross Corporation in the 1980s. It is also being studied for use in liquid breathing. Perfluorodecalin can be applied topically, to provide extra oxygen to a specific location, to accelerate wound healing. Organs and tissues can be stored for longer in oxygenated perfluorodecalin; the "two-layer method" uses perfluorodecalin and UW solution to preserve tissue for pancreas transplants.

* Periodontal Disease, also known as periodontal diseases, is related to tuberculosis and peripheral vascular disease, and has symptoms including halitosis, snoring and tenderness of gums. An important gene associated with Periodontal Disease is IL1B (Interleukin 1 Beta), and among its related pathways are Interleukin-1 processing and Dendritic Cells Developmental Lineage Pathway. The drugs chlorhexidine gluconate and chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and t cells, and related mouse phenotypes are limbs/digits/tail and renal/urinary system. A set of inflammatory diseases affecting the tissues surrounding the teeth.

* Periodontitis, Chronic, also known as chronic periodontitis, is related to chronic apical periodontitis and periodontitis, and has symptoms including gingivitis and periodontitis. An important gene associated with Periodontitis, Chronic is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs sodium fluoride and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, ovary and liver, and related phenotypes are immune system and neoplasm. This is the most frequently occurring form of periodontitis and is characterized by slowly progressing alveolar bone destruction and attachment loss. Although chronic periodontitis is most prevalent in adults and has a slow progression, it can occur in children and adolescents and may have periods of rapid progression.

* Periostitis is related to periodontal disease and rheumatoid arthritis. An important gene associated with Periostitis is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, lung and endothelial. A medical condition caused by inflammation of the periosteum, a layer of connective tissue that surrounds bone.

* Peripheral Artery Disease, also known as peripheral arterial diseases, is related to critical limb ischemia and peripheral vascular disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Peripheral Artery Disease is CDKN2B-AS1, and among its related pathways/superpathways are Innate Immune System and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and bone, and related phenotypes are Decreased free cholesterol and cardiovascular system. A narrowing of the arteries other than those that supply the heart or the brain.

* Peripheral Nervous System Disease, also known as peripheral neuropathy, is related to motor peripheral neuropathy and sensory peripheral neuropathy, and has symptoms including back pain, headache and neuralgia. An important gene associated with Peripheral Nervous System Disease is IARS2 (Isoleucyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Neuroscience and Guidance Cues and Growth Cone Motility. The drugs Naproxen and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, lung and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2). A nervous system disease that affects the peripheral nervous system.

* Peripheral Vascular Disease, also known as arterial occlusive disease, is related to artery disease and limb ischemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Peripheral Vascular Disease is VWF (Von Willebrand Factor), and among its related pathways are Dissolution of Fibrin Clot and Malaria. The drugs streptokinase and papaverine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and endothelial, and related mouse phenotypes are Decreased free cholesterol and neoplasm. A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.

* Peripheral Vertigo, also known as vertigo, peripheral, is related to acute infection of pinna and med13l syndrome, and has symptoms including vertigo An important gene associated with Peripheral Vertigo is CRP (C-Reactive Protein), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include neutrophil, and related mouse phenotypes are homeostasis/metabolism and mortality/aging. A problem with the inner ear, which controls balance.

* Peritonitis, also known as retractile mesenteritis, is related to primary peritoneal carcinoma and tuberculous peritonitis. An important gene associated with Peritonitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Ertapenem and Mupirocin have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor). Peritonitis is inflammation of the peritoneum, the lining of the inner wall of the abdomen and cover of the abdominal organs.

* Peroneal Nerve Paralysis, also known as peroneal nerve palsy, is related to osteopetrosis and thrombotic thrombocytopenic purpura. An important gene associated with Peroneal Nerve Paralysis is TBXAS1 (Thromboxane A Synthase 1). A paralysis on common fibular nerve that affects patient’s ability to lift the foot at the ankle. Peroneal nerve paralysis usually leads to neuromuscular disorder, peroneal nerve injury, or foot drop.

* Peroneal Neuropathy, also known as peroneal neuropathies, is related to neuropathy and hereditary orotic aciduria without megaloblastic anaemia. An important gene associated with Peroneal Neuropathy is LITAF (Lipopolysaccharide Induced TNF Factor), and among its related pathways are Dendritic Cells Developmental Lineage Pathway and Hematopoietic cell lineage. Affiliated tissues include endothelial, liver and bone.

* Personality Disorder, also known as personality disorders, is related to schizoid personality disorder and obsessive-compulsive personality disorder, and has symptoms including pseudobulbar behavioral symptoms, restlessness and personality changes. An important gene associated with Personality Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Transmission across Chemical Synapses. The drugs Fluvoxamine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are shRNA abundance <= 50% and behavior/neurological. A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

* Pertussis, also known as whooping cough, is related to neutrophil migration and pneumonia, and has symptoms including fever, pruritus and snoring. An important gene associated with Pertussis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Montelukast and Edetic Acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and neutrophil, and related phenotypes are homeostasis/metabolism and hematopoietic system. Whooping cough is an infectious bacterial disease that causes uncontrollable coughing.

* PF-00446687 is a drug developed for the treatment of erectile dysfunction, which is a non-peptide agonist selective for the melanocortin receptor subtype MC4. It was found to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective. While it is unclear whether PF-00446687 itself will be potent and effective enough to be developed for medical use, it has demonstrated that selectively targeting the MC4 subtype can produce similar aphrodisiac effects to older non-selective peptide-based melanocortin receptor agonists like melanotan II and bremelanotide, without the side effects caused by action at the other melanocortin receptor subtypes.

* PF-232798 is a new entry inhibitor that stops HIV from entering cells. It may have potential anti-HIV activity against strains of HIV resistant to maraviroc.

* PF-739 was capable of lowering blood glucose in 1 hr. Evaluation of AMPK activity in tissues showed that PF-739 resulted in increased AMPK phosphorylation in liver tissue. Moreover PF-739 caused an increase in AMPK activity, as assessed by ACC phosphorylation, in the skeletal muscle.The glucose-lowering effect of PF-739 resulted in an increase in the rate of glucose disposal, but had no impact on the endogenous glucose production (EGP) rate. This effect was consistent with activation of AMPK in the skeletal muscle with PF-739 and in the liver. These results indicate that the glucose-lowering phenotype of PF-739 is due to increases in systemic glucose uptake with no impact on hepatic glucose output. In contrast to the liver, activation of AMPK in the skeletal muscle is associated with glucose lowering and increased muscle glucose disposal, suggesting that AMPK activation in the skeletal muscle continues to hold promise as a therapeutic strategy to treat T2DM.

* PHA-543613 is a drug that acts as a potent and selective agonist for the alfa7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.

* Phenibut is a central nervous system (CNS) depressant and derivative of the naturally occurring inhibitory neurotransmitter gamma-aminobutyric acid (GABA). The addition of a phenyl ring allows phenibut to cross the blood–brain barrier. Phenibut is sold as a nutritional supplement. In Russia it is sold as a psychotropic drug. It has been reported by some to possess nootropic actions for its ability to improve neurological functions, but other researchers have not observed these effects. It is generally accepted that phenibut has anxiolytic effects in both animal models and in humans. Phenibut was discovered in the Soviet Union in the 1960s, and has since been used there to treat a wide range of ailments including post-traumatic stress disorder, anxiety, and insomnia. Phenibut is mandated standard equipment in a Russian cosmonaut's medical kit.

* Phosphodiesterase 10A (PDE10A) is a basal ganglia expressed dual substrate enzyme, which regulates cAMP and cGMP signalling cascades, thus having a key role in the regulation of dopaminergic signalling in striatal pathways, and in promoting neuronal survival. Striatal and pallidal loss of PDE10A expression, is associated with Parkinson’s duration and severity of motor symptoms and complications. PDE10A is an enzyme that could be targeted with novel pharmacotherapy to improve dopaminergic signalling and striatal output, and therefore alleviate symptoms and complications of Parkinson’s disease.

* Photokeratitis is related to interdigitating dendritic cell sarcoma and diabetic foot ulcers. An important gene associated with Photokeratitis is TCF12 (Transcription Factor 12), and among its related pathways/superpathways are Innate Immune System and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include eye, skin and brain, and related phenotypes are hematopoietic system and immune system. Photokeratitis or ultraviolet keratitis is a painful eye condition caused by exposure of insufficiently protected eyes to the ultraviolet (UV) rays from either natural (e.g. intense sunlight) or artificial (e.g. the electric arc during welding).

* Photoregulin3 alters the activity of a transcription factor that regulates rod genes. In follow-up experiments, mice with a mutation that replicates many of the features of retinitis pigmentosa were given Photoregulin3 to see if it could slow the progression of the disease. Indeed, Photoregulin3 could stop many of the rod cells from degenerating in the treated mice. At the end of the experiment, the mice treated with this small molecule had about twice as many rods as the control mice. The treated mice also responded better to flashes of light.

* Phylloquinone, also Vitamin K1, is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants, particularly leaves, since it functions as an electron acceptor during photosynthesis, forming part of the electron transport chain of Photosystem I. Its best-known function in animals is as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX, and X by the liver. It is also required for the formation of anticoagulant factors protein C and S. It is commonly used to treat warfarin toxicity, and as an antidote for coumatetralyl. Vitamin K is required for bone protein formation. * RPL-554 is a “first-in-class” drug under development for chronic obstructive pulmonary disease (COPD), asthma, allergic rhinitis, inflammation.and cystic fibrosis. The drug is an inhibitor of the phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) enzymes, two enzymes known to be of importance in the development and progression of immunological respiratory diseases. The drug has the potential to act as both a bronchodilator and an anti-inflammatory which would significantly differentiate it from existing drugs.

* Physical endurance profile gene therapy (revised and updated) is based upon Dr. Henning Wakerhage's notes to produce enhanced physical performance. The recording plays 150s each item, ACVR2B as Myostatin inhibitor, Glyc Synthase GYS1, EPO, PPAR-gamma, ACTN3 (1-576) to turn down the whole gene, PGC-1alpha or PPARGC1A, MEK1 or MAP2K1, PEPCK1 cytosolic, MAPK12, GH1, Ras or AGTR2, Calcineurins, PI3K, IGF1, and MK-2206 as PKB inhibitor in order.

Rationale
Muscle hypertrophy (-) Myostatin inhibitor ACVR2B
Raised muscle glycogen (+) Glyc Synthase GYS1
Higher haematocrit (+) EPO
Fibre type and mitochondria biogenesis (+), for endurance running (-) PPAR-gamma
Fibre type (-) ACTN3 1-576
Fibre type and mitochondria biogenesis (+) PGC-1alpha or PPARGC1A
Myocardial hypertrophy (+) MEK1 or MAP2K1
Endurance running (+) PEPCK1 cytosolic
Fibre type (+) MAPK12
Longer legs (+) GH or GH-1
Fibre type (+) Ras AGTR2
Fibre type (+) Calcineurins PPP3CA
Myocardial hypertrophy (+) PI3K
Muscle hypertrophy (+) IGF1
Muscle hypertrophy (-) PKB inhibitor MK-2206
(+)(-) refers to turning up or down gene' expression

* Physical performance-injury healing peptides. Each item plays for five minutes ten seconds. In playing order,
- Thymosin Beta 4 TB500 peptide can influence the performance of athletes, it also plays an important role in protection, regeneration and remodeling of injured and/or damaged tissues. TB 500 utilizes two mechanisms to promote and expedite healing. First it has a direct effect on Actin. Actin is a hair like substance that surrounds cells. It is responsible for the movement, growth and binding of cells. It plays a crucial role in healing. Second it is responsible for the activation of cells known as progenitor cells. These cells are unique in that they can assimilate with different cell types. They also produce protein and growth factors that promote healing.
- Body Protection Compound-157 BPC 157 peptide exhibits the capacity to regulate and control the manner in which the digestive tract can operate. One of the ways that BPC 157 accomplishes this is through safeguarding the endothelium, which is the thin layer of cells that line the blood vessels’ interior surface. Another way the peptide carries out regulatory function is by being a key factor in the process of angiogenesis; that is, the process in which new blood vessels are formed from pre-existing blood vessels. This latter process is further bolstered by BPC 157’s ability to form granulation tissue; this term references the new connective tissues and tiny blood vessels that develop on the surface of wound, thus making the peptide an important piece to the overall wound healing process. Further studies have also shown that the peptide’s inherent functionality allows it to contain anti-inflammatory properties. BPC 157 increases the migration and spreading of tendon fibroblasts. Finally, BPC 157 also increases the probability of a cell surviving under oxidative stress.

* Pidilizumab is a monoclonal antibody designed for the treatment of cancer and infectious diseases.

* Pigmentation Disease, also known as pigmentation disorders, is related to hypomelanosis of ito and dyschromatosis symmetrica hereditaria, and has symptoms including exanthema, pruritus and polydipsia. An important gene associated with Pigmentation Disease is TYR (Tyrosinase), and among its related pathways are Estrogen metabolism and Constitutive Androstane Receptor Pathway. Affiliated tissues include skin, and related mouse phenotypes are limbs/digits/tail and integument. Disturbances of human skin color, either loss or reduction, which may be related to loss of melanocytes or the inability of melanocytes to produce melanin or transport melanosomes correctly.

* Pimecrolimus is an immunomodulating agent of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema). It has been proven to be effective in various inflammatory skin diseases, e.g., seborrheic dermatitis, cutaneous lupus erythematosus, oral lichen planus, vitiligo, and psoriasis. Pimecrolimus is an ascomycin macrolactam derivative. It has been shown in vitro that pimecrolimus binds to FKBP1A and also inhibits calcineurin. Thus pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells. Pimecrolimus also prevents the release of inflammatory cytokines and mediators from mast cells. In contrast with topical steroids, pimecrolimus does not produce skin atrophy.

* Pinabulin is a novel small molecule that is being developed for the mitigation of chemotherapy-induced neutropenia. Administered by IV infusion on the same day of (approximately 1 h after) chemotherapy, plinabulin will be given in a single dose of 20 mg/m2 per cycle. Plinabulin has the potential to be an effective, safe (with much less bone pain), cost-effective, and convenient alternative to G-CSF for the prevention of chemotherapy-induced neutropenia.

* Pirfenidone is a medication used for the treatment of idiopathic pulmonary fibrosis. It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. Pirfenidone can also treat liver fibrosis, scars, skin ulcers and fibrotic tissue. Pulmonary fibrosis, which is a hardening of the tissues of the lung that prevents its proper functioning is one of the long-term effects that Covid-19 could leave.

* Pitrakinra is a human recombinant protein. It is an interleukin 4 (IL-4) and interleukin 13 (IL-13) antagonist. Asthma results from a dysregulated, hyperresponsive immune response in the airways. Some immune cells in allergic asthmatics respond aggressively to foreign allergens with the release of IL-4 and 13, two key mediators that initiate a cycle of inflammation in the lung.

* Pituitary Adenoma, Growth Hormone-Secreting, also known as growth hormone secreting pituitary adenoma, is related to pituitary adenoma, acth-secreting and usher syndrome, type 1f, and has symptoms including coarse facial features, frontal bossing and hypertrophic cardiomyopathy. An important gene associated with Pituitary Adenoma, Growth Hormone-Secreting is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and G-protein signaling_RhoA regulation pathway. The drugs Octreotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary and thyroid. A benign pituitary gland tumor that leads to the production of too much growth hormone, resulting in acromegaly.

* Pituitary Gland Disease, also known as pituitary dysfunction, is related to retinal dystrophy, early-onset, and pituitary dysfunction and microphthalmia, syndromic 5, and has symptoms including back pain, headache and pain. An important gene associated with Pituitary Gland Disease is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and p70S6K Signaling. The drugs Menthol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region. An endocrine system disease that is located in the pituitary gland.

* PJ34 is a small molecule used to treat stroke victims. PJ34 also is seen to offer ‘great potential’ for causing the aggressive tumor, as well as others, to self-destruct in humans. PJ34 induced the self-destruction of pancreatic cancer cells in mice. The treatment reduced the number of cancer cells by as much as 90 percent a month after being administered, according to a study. Pancreatic cancer is currently resistant to all treatments, and patients have poor chances of surviving for five years after being diagnosed. This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death. Thus, cell multiplication itself resulted in cell death in the treated cancer cells. Furthermore, the PJ34 molecule “exclusively” affected the human cancer cells, but left benign ones unaffected. No adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behavior. In parallel studies, the research team found that the molecule “acts efficiently” when they tested it on other types of deadly cancer cell cultures in the lab, including aggressive forms of breast, lung, brain and ovarian cancer, all of which are resistant to current therapies.

* PLAT factor or tissue plasminogen activator (abbreviated tPA) is a protein involved in the breakdown of blood clots. It is a serine protease found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA used in clinical medicine to treat embolic or thrombotic stroke. Use is contraindicated in hemorrhagic stroke and head trauma. tPA is used in some cases of diseases that feature blood clots, such as pulmonary embolism, myocardial infarction, and stroke, in a medical treatment called thrombolysis. It has been suggested that if tPA is effective in ischemic stroke, it must be administered as early as possible after the onset of stroke symptoms. tPA and plasmin are the key enzymes of the fibrinolytic pathway in which tPA mediated plasmin generation occurs. tPA cleaves the zymogen plasminogen into the serine protease plasmin. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding. Decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. In ischemic stroke patients, decreased tPA activity was reported to be associated with an increase in plasma P-selectin concentration. Tissue plasminogen activator also plays a role in cell migration and tissue remodeling.

* Plecanatide is a drug approved for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP. The symptoms should also have been present for at least three of the last six months to establish the chronic nature of the condition before treatment with Plecanatide is indicated. Use of Plecanatide by persons under the age of 6 poses a serious dehydration risk and studies have demonstrated Plecanatide can cause death in juvenile mice due to this dehydrating effect. Use of Plecanatide is also contraindicated in persons who are suspected of having a mechanical gastrointestinal obstruction.

* PLEKHA7 factor recruits the so-called "microprocessor complex" (association of DROSHA and DGCR8 proteins) to a growth-inhibiting site (apical zonula adherens) in epithelial cells instead of sites at basolateral areas of cell–cell contact containing tyrosine-phosphorylated p120 and active Src. Recruitment to the latter sites disrupts miRNAs regulation, causing tumorigenic growth. Restoring normal miRNA levels in tumor cells can reverse that aberrant cell growth. Loss of the apical PLEKHA7-microprocessor complex is an early and somewhat universal event in cancer. In most human tumor samples this apical structure is absent, although E-cadherin and p120 are still present. This produces the equivalent of a speeding car that has a lot of gas (the bad p120) and no brakes (the PLEKHA7-microprocessor complex).

* Plerixafor is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. In the form of its zinc complex, plerixafor acts as an antagonist (or perhaps more accurately a partial agonist) of the alpha chemokine receptor CXCR4 and an allosteric agonist of CXCR7. The CXCR4 alpha-chemokine receptor and one of its ligands, SDF-1, are important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. The in vivo effect of plerixafor with regard to ubiquitin, the alternative endogenous ligand of CXCR4, is unknown. Plerixafor has been found to be a strong inducer of mobilization of hematopoietic stem cells from the bone marrow to the bloodstream as peripheral blood stem cells. Additionally, plerixafor inhibits CD20 expression on B cells by interfering with CXCR4/SDF1 axis that regulates its expression.

* Plexopathy is related to radiation induced brachial plexopathy and sacral plexopathy. An important gene associated with Plexopathy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways are SIDS Susceptibility Pathways and Neuroscience. Affiliated tissues include bone, myeloid and lung, and related mouse phenotypes are muscle and behavior/neurological. A disorder affecting a network of nerves, blood vessels, or lymph vessels.

* PLG factor or Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots. The degradation of fibrin is termed fibrinolysis. Plasmin is a serine protease that acts to dissolve fibrin blood clots. Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. In circulation, plasminogen adopts a closed, activation resistant conformation. Upon binding to clots, or to the cell surface, plasminogen adopts an open form that can be converted into active plasmin by a variety of enzymes, including tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately. Plasminogen deficiency in mice leads to defective liver repair, defective wound healing, reproductive abnormalities. It might be used as add-on in the management of diabetes, hypertension, hypercholesterolemia, stroke, ischemic heart disease and other conditions associated with hypercoagulation. It might improve the circulation of blood by gradually dissolving blood clots inside the veins therefore minimizing the risk of heart attacks and strokes.

* Plica Syndrome is related to acrorenal syndrome and malignant type ab thymoma, and has symptoms including arthralgia, joint swelling and joint stiffness. An important gene associated with Plica Syndrome is ELN (Elastin), and among its related pathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone and testes. A condition which occurs when a plica (an extension of the protective synovial capsule of the knee) becomes irritated, enlarged, or inflamed.

* PLP139-151 myelin proteolipid protein (PLP). Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE). PLP139-151 overrides a defect in antigen presentation responsible for resistance to EAE, natural processing and presentation of neuroantigens during the course of acute EAE induces Th2 cells that prevent the relapse of multiple sclerosis (MS).

* Plumbagin is an organic compound with antimicrobial, antimalarial, anti-inflammatory, anticarcinogenic, cardiotonic, immunosuppressive, antifertility action, neuroprotective, and anti-atherosclerosis effects.

* Plumericin is a potent inhibitor of NF-kappaB pathways with a new chemical scaffold. It could be further explored as a novel anti-inflammatory lead compound.

* PM-43I can inhibit STAT6-dependent allergic airway disease in mice. Moreover, PM-43I reversed preexisting allergic airway disease in mice. Importantly, PM-43I was efficiently cleared through the kidneys and had no long-term toxicity. PM-43I represents the first of a class of small molecules that may be suitable for further clinical development as a therapeutic drug against asthma. Steroids prevent inflammation as well as other immune responses. The researchers' work shows that treating asthma with PM-43I may control asthma without impairing the ability of the body to fight pathogens. Steroids drive down all the immune system, but this small molecule specifically targets the pathway that leads to asthma, uncompromising the other pathways that allow the body to fight disease. Treatment alone would be able to control the asthma. PM-43I prevents the induction of fungal-induced asthma and, more importantly, reverses many of the hallmark features of asthma including airway constriction, lung inflammation, and lung mucus production.

* PMPAEDIVDLAYES peptide from E. dysenterica has the ability to stimulate motility without causing diarrhea. In addition, the laxative peptide has been seen to promote a different and toxicity free activity than other commercial laxatives.

* PNPLA3 gene. A common mutation in this gene combined with overweight results in elevated ALAT values in children. The ALAT value is an indicator of liver metabolism. In adults, this gene mutation is known to promote the accumulation of fat in the liver. The new results indicate that a healthy lifestyle is important already in childhood in order to prevent the accumulation of fat in the liver, and it is especially important for those carrying the risk gene.

* Polaprezinc is a chelate of zinc and L-carnosine. The compound maintains homeostasis of the gastric mucosa by prostaglandin-independent cytoprotective effects due to anti-oxidative membrane stabilizing actions, and it promotes the repair of damaged tissues by wound healing action. It has a stimulatory effect on bone formation and a restorative effect on bone loss under various pathophysiologic conditions. ‘Leaky gut’ is a condition where the thin mucosal barrier of the gut, which plays a role in absorbing nutrients and preventing large molecules and germs from the gut entering the blood stream, becomes less effective. It is a particular problem for those taking part in heavy exercise or who are active in hot conditions. It can lead to ‘heat stroke’ (especially in military personnel deployed to countries with high temperatures) and gut symptoms in athletes. It may be helpful for anyone exercising at their peak in hot and humid conditions.

* Pollen Allergy, also known as hay fever, is related to esophagitis, eosinophilic, 1 and rhinitis, and has symptoms including coughing, snoring and tinnitus. An important gene associated with Pollen Allergy is CD164 (CD164 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes, and related phenotypes are hematopoietic system and immune system. A respiratory allergy triggered by pollen.

* Polybia-MP1 peptide is an helical peptide extracted from the venom of a Brazilian wasp, it has broad-spectrum antimicrobial activities without being hemolytic or cytotoxic. This peptide has also displayed anticancer activity against cancer cell cultures. Its activity is attributed to the excess of serine (PS) on the outer leaflet of cancer cells. Recently, higher quantities of ethanolamine (PE) were also found in these cells. The permeabilization effect due to MP1 action is dependent on the lipid composition. Presence of PE increases the rate and the extent of dye leakage, suggesting that it has important influence on MP1's potency, giving basis for the peptide specificity for cancer cells.

* Polycarbophil is a drug used as a stool stabilizer. Chemically, it is a synthetic polymer of polyacrylic acid cross-linked with divinyl glycol, with calcium as a counter-ion. t is used as stool stabilizer to treat constipation, diarrhea and abdominal discomfort. Bulk laxatives absorb liquid in the intestines and swell to form a soft bulky stool. The bulky mass stimulates the intestinal muscles, speeding stool transit time through the colon. Results usually occur within 12 to 72 hours. Calcium polycarbophil will not work without increased fluid intake. Calcium polycarbophil has been marketed as an over-the-counter agent used for treating functional bowel disorder and as a bulk-producing agent. A study looked at the effects of calcium polycarbophil on general irritable bowel syndrome (IBS) symptoms. Fourteen patients with IBS-diarrhea and twelve with IBS-constipation were given calcium polycarbophil for eight weeks and their colon transit times were measured with radiopaque markers in the colon. The patients with diarrhea reported fewer bowel movements, more solid stools and reduced abdominal pain. Patients with constipation reported more frequent bowel movements, looser stools and less pain.

* Polyglutamic acid acts as an anti-wrinkle agent, emulsifier, lightening/whitening agent and moisturizing agent. It is a natural occurring, multi-functional, and biodegradable biopolymer produced through fermentation by bacillus subtilis using glutamic acid. PGA is consists of glutamic acid monomers cross-linked between alpha-amino and gamma-carboxyl groups. It is water-soluble. It helps to improve skin quality and reduces skin wrinkle conditions. Used in skin care formulations.

* Polymyxin B and Bacitracin are a topical, otic, and ophthalmological antibiotic mixture.

* Polyradiculopathy is related to cauda equina syndrome and polyradiculoneuropathy. An important gene associated with Polyradiculopathy is COL6A1 (Collagen Type VI Alpha 1 Chain), and among its related pathways are Heart Development and Degradation of the extracellular matrix. Affiliated tissues include cervix. Radiculopathy refers to a set of conditions in which one or more nerves are affected and do not work properly (a neuropathy). The location of the injury is at the level of the nerve root (radix = "root"). This can result in pain (radicular pain), weakness, numbness, or difficulty controlling specific muscles.

* Polysubstance Abuse, also known as polysubstance abuse, susceptibility to, is related to substance dependence and pathological gambling. An important gene associated with Polysubstance Abuse is FAAH (Fatty Acid Amide Hydrolase), and among its related pathways/superpathways are Circadian entrainment and Monoamine GPCRs. The drugs Cocaine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and b cells, and related phenotypes are behavior/neurological and homeostasis/metabolism. A patterned use of more than one drug in which the user consumes the substance in amounts or with methods which are harmful.

* Polytrim is an antimicrobial compound for ophthalmic use in the treatment of acute bacterial conjunctivitis and blepharoconjunctivitis.

* Ponericin-G1 peptide is derived from Pachycondyla goeldii ant venom. Presents broad antibacterial and antifungal spectrum. Has marked insecticidal and non-hemolytic activities.

* Ponesimod is an experimental drug for the treatment of multiple sclerosis (MS) and psoriasis.

* Portal Hypertension, also known as hypertension, portal, is related to esophageal varix and congenital hepatic fibrosis, and has symptoms including signs and symptoms, digestive An important gene associated with Portal Hypertension is DGUOK (Deoxyguanosine Kinase), and among its related pathways/superpathways are Signaling by GPCR and PEDF Induced Signaling. The drugs Spironolactone and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and endothelial, and related phenotypes are homeostasis/metabolism and growth/size/body region. Portal hypertensioni s abnormally high blood pressure in branches of the portal vein, the large vein that brings blood from the intestine to the liver. Portal hypertension itself does not cause symptoms, but complications from the condition can lead to an enlarged abdomen, abdominal discomfort, confusion, drowsiness and internal bleeding. Cirrhosis (a form of chronic liver failure) is the most common cause of portal hypertension.

* Portal Vein Thrombosis is related to liver cirrhosis and hypersplenism. An important gene associated with Portal Vein Thrombosis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Collagen chain trimerization and Response to elevated platelet cytosolic Ca2+. The drugs Benzocaine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and pancreatic islet, and related phenotypes are homeostasis/metabolism and integument. A form of venous thrombosis affecting the hepatic portal vein, which can lead to portal hypertension and reduction in the blood supply to the liver.

* Post-herpetic neuralgia gene therapy, the frequencies of products and gene factors for relief.
In playing order, Tanezumab (4m), CALCA (2m), TRPV1 (2m), SCN3A iso 3 (2m), SCN3A iso1 (2m), SCN3A iso 4 (2m), SCN3A iso 2 (2m), SCN10A (2m), GRIN2B (2m), IL10 (2m), NMDA (4m).

* Postmenopausal Atrophic Vaginitis, also known as atrophic vaginitis, is related to comedo carcinoma and deafness, autosomal dominant 8/12. An important gene associated with Postmenopausal Atrophic Vaginitis is PRLR (Prolactin Receptor), and among its related pathways/superpathways are Prolactin Signaling Pathway and TGF-beta Signaling Pathways. The drugs Hyaluronic acid and Apricot have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and adipose tissue. An inflammation of the vagina (and the outer urinary tract) due to the thinning and shrinking of the tissues, as well as decreased lubrication. These symptoms are due to a lack of the reproductive hormone estrogen.

* Post-Thrombotic Syndrome (update to RT-MB 26 item) , also known as postphlebitic syndrome, is related to chronic venous insufficiency and thrombosis. An important gene associated with Post-Thrombotic Syndrome is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Toll-like Receptor Signaling Pathway. The drugs Dalteparin and Enoxaparin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are cardiovascular system and hematopoietic system. A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis.

* Post-Thrombotic Syndrome, also known as postphlebitic syndrome, is related to lymphedema and thrombophilia, and has symptoms including mahler sign An important gene associated with Post-Thrombotic Syndrome is F5 (Coagulation Factor V), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Immune response MIF-mediated glucocorticoid regulation. Affiliated tissues include skin, testes and bone, and related mouse phenotypes are integument and cardiovascular system. A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis.

* Post-Traumatic Stress Disorder, also known as stress disorders, post-traumatic, is related to traumatic brain injury and brain injury, and has symptoms including nervousness An important gene associated with Post-Traumatic Stress Disorder is LINC01090, and among its related pathways/superpathways are Circadian entrainment and Amphetamine addiction. The drugs Diazepam and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related phenotypes are homeostasis/metabolism and behavior/neurological. An anxiety disorder which results from a traumatic experience that results in psychological trauma.

* PQBP1 factor provides instructions for making a protein called polyglutamine-binding protein 1. Missense mutations, small and gross deletions, as well as small insertions in this gene may cause intellectual disability and dysmorphisms. Knock-down of PQBP1 in a mouse model impairs anxiety-related cognition -the crucial inflection point between moderate and high cognitive load, where resources shift from anxious apprehension to focus on task demands.

* PQQ-CoQ10. Pyrroquinoline quinone or PQQ is a synthetic molecule. There is some evidence in a most compelling study that showed PQQ and CoQ10 could improve verbal memory performance whereas either alone could not. PQQ and CoQ 10 promote antioxidant activity and mitochondrial health through different mechanisms, providing multifunctional support for cardiovascular health and neuroprotection. PQQ is an ideal complement to CoQ10 because PQQ stimulates the growth and replication of those same mitochondria. More mitochondria with more spark means even more energy.

* Pralatrexate is an anti-cancer therapy for patients with relapsed or refractory peripheral T-cell lymphoma, or PTCL are a biologically diverse group of aggressive blood cancers that have a poor prognosis. Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells. Antifolates, such as pralatrexate, are part of a group of compounds known as antimetabolites with structural similarity to naturally occurring molecules involved in DNA synthesis. Cancer cells mistake antimetabolites for normal metabolites allowing the compound to stop or slow critical enzymes involved in DNA synthesis which then triggers cell death. Because of their primary effect on DNA synthesis, the antimetabolites are most effective against actively dividing cells and are largely cell-cycle phase specific. (Among the top most expensive meds - Folotyn)

* Prediabetes Syndrome, also known as prediabetic state, is related to nonalcoholic steatohepatitis and fatty liver disease. An important gene associated with Prediabetes Syndrome is INS (Insulin), and among its related pathways/superpathways are Glucose / Energy Metabolism and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region. The precursor stage before diabetes mellitus in which not all of the symptoms required to diagnose diabetes are present, but blood sugar is abnormally high.

* Prepronociceptin PNOC is the ligand of the nociceptin receptor (NOP). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.

* Presbyopia is related to refractive error and cycloplegia, and has symptoms including aniseikonia An important gene associated with Presbyopia is CRYAA (Crystallin Alpha A). Affiliated tissues include eye, testes and cortex, and related mouse phenotype vision/eye. A condition associated with aging of the eye that results in progressively worsening ability to focus clearly on close objects. Symptoms include a hard time reading small print, having to hold reading material farther away, headaches, and eyestrain.

* Presenilins PSEn1-PSEN2. Mutations in the PSEN1 factor are the most common cause of inherited, early-onset forms of Alzheimer's disease, frontotemporal dementia, dilated cardiomyopathy, and familial acne inversa. Mutations in the PSEN2 factor are the most common cause of inherited, early-onset forms of Alzheimer's disease, and dilated cardiomyopathy. Whereas partial loss of presenilins (PSEN1 and PSEN2) causes seborrheic keratosis and autoimmune disease in mice. PSEN1 right channel, PSEN2 left channel.

* PRG4 factor encodes proteoglycan 4 or lubricin. This proteoglycan acts as a joint/boundary lubricant. It also prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. The expression of lubricin has also been detected and the protein localized in tendon, meniscus, lung, liver, heart, bone, ligament, muscle, and skin.

* Primary Bacterial Infectious Disease is related to trench fever and syphilis. An important gene associated with Primary Bacterial Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are cellular and growth/size/body region. A bacterial infectious disease that results in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.

* Primary Systemic Mycosis is related to sporotrichosis and coccidioidomycosis. An important gene associated with Primary Systemic Mycosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include t cells, skin and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2). A systemic mycosis that results in infection located in human body, has material basis in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

* Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens, and is the major progestogen in the body. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. Elevated levels of progesterone potently reduce the sodium-retaining activity of aldosterone, resulting in natriuresis and a reduction in extracellular fluid volume. Progesterone withdrawal, on the other hand, is associated with a temporary increase in sodium retention (reduced natriuresis, with an increase in extracellular fluid volume) due to the compensatory increase in aldosterone production, which combats the blockade of the mineralocorticoid receptor by the previously elevated level of progesterone. Since most progesterone in males is created during testicular production of testosterone, and most in females by the ovaries, the shutting down (whether by natural or chemical means), or removal, of those inevitably causes a considerable reduction in progesterone levels. The tendency for progesterone to have a regulatory effect, the presence of progesterone receptors in many types of body tissue, and the pattern of deterioration (or tumor formation) in many of those increasing in later years when progesterone levels have dropped, is prompting widespread research into the potential value of maintaining progesterone levels in both males and females.

* Propofol produces loss of consciousness rapidly. Its duration of action is short with a mean of 3 to 5 minutes. Studies investigating the recovery profile of propofol have reported that patients anaesthetized with propofol wake-up “elated”, “euphoric”, and “talkative”. Clinical studies indicate that 50% of participating subjects reported “liking” on the Visual Analog Scale and showed preference for propofol over placebo. Sub-anesthetic doses of propofol are reported to produce feelings of “being high”, light-headedness, spaced out and sedation. Propofol at anesthetic doses is reported to cause dream incidence in 20% to 60% of the exposed population. The primary effect of propofol is potentiation of GABA-A receptors. Similar to barbiturates and benzodiazepines, propofol has been shown to produce rewarding and reinforcing effects in animals. Sub-anesthetic and anesthetic doses of propofol have been shown to increase dopamine concentrations in the nucleus accumbens (brain reward system) in rats. Propofol has a fast onset of action and crosses the blood-brain barrier very quickly. Its short duration of action is due to rapid distribution from the central nervous system to other tissues.

* Prostacyclin is a prostaglandin member of the family of lipid molecules known as eicosanoids. Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It does this by inhibiting platelet activation. It is also an effective vasodilator.

* Prostate cancer: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. A male reproductive organ cancer that is located in the prostate.

* Prostatic Hyperplasia, Benign, also known as benign prostatic hyperplasia, is related to prostatic adenoma and prostatic hypertrophy, and has symptoms including prostatism An important gene associated with Prostatic Hyperplasia, Benign is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Bupivacaine and Doxazosin have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney, and related phenotype is benign prostatic hyperplasia. Also called prostate enlargement, is a noncancerous increase in size of the prostate.

* Protein-Energy Malnutrition, also known as pem, is related to hypervitaminosis a and malaria, and has symptoms including cachexia and emaciation. An important gene associated with Protein-Energy Malnutrition is ALB (Albumin), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Morphine and Naproxen have been mentioned in the context of this disorder. Affiliated tissues include liver, prostate and brain, and related phenotypes are homeostasis/metabolism and hematopoietic system. A form of malnutrition which is defined as a range of pathological conditions arising from coincident lack of protein and/or energy in varying proportions.

* Prucalopride is a drug acting as a selective, high affinity serotonin (5-HT4) receptor agonist which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements. The drug has also been tested for the treatment of chronic intestinal pseudo-obstruction. Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease, and ulcerative colitis and toxic megacolon/megarectum. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.

* Pseudomonas-NicA2 factor or Putative nicotine oxyreductase found in the bacteria Pseudomonas putida degrades nicotine. Research shows that reduces the half-life of nicotine to nine minutes from two to three hours.

* Psychosexual Disorder, also known as psychosexual disorders, is related to rumination disorder and functional gastric disease, and has symptoms including genital pain An important gene associated with Psychosexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Calcium signaling pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Apremilast and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include spinal cord. A sexual problem that is psychological, rather than physiological in origin.

* Psychotic Disorder, also known as psychotic disorders, is related to schizophrenia 9 and schizophrenia, and has symptoms including alexithymia, decreased libido and increased libido. An important gene associated with Psychotic Disorder is DISC1 (Disrupted In Schizophrenia 1), and among its related pathways/superpathways are Neuroscience and Circadian rythm related genes. The drugs Aripiprazole and Asenapine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological. A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.

* PT-141 Bremelanotide peptide was shown to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system.

* PTK2 factor is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). Aberrant PTK2/FAK1 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. PTK2/FAK1 overexpression is seen in many types of cancer. In cardiac muscle, ischemia reperfusion (IR) injury is attenuated by mitochondrial function, which may be upregulated by focal adhesion kinase (FAK). IR-induced skeletal muscle rhabdomyolysis is a fiber type-specific phenomenon that appears to be modulated by mitochondria reserves. Stimulation of FAK may exploit these reserves constituting a potential therapeutic approach to reduce tissue loss following acute limb IR in fast-type muscle.

* PTRF polymerase I and transcript release factor (left channel) and MG53 tripartite motif-containing protein 72 factor (right channel). Throughout the lifecycle, injury to the body's cells occurs naturally, as well as through trauma. Cells have the ability to repair and regenerate themselves, but a defect in the repair process can lead to cardiovascular, neurological, muscular or pulmonary diseases. Recent discoveries of key genes that control cell repair have advanced the often painstaking search for ways to enhance the repair process. The protein MG53, previously shown to be the key initiator in the cell membrane repair process, has the potential to be used directly as a therapeutic approach to treating traumatic tissue damage. MG53 slows the development of the disease by repairing damaged muscle membranes and, it could be used in regenerative medicine to treat other human diseases in which traumatic cell injury occurs. However, in order for MG53 to successfully repair damaged tissue, it must work cooperatively with PTRF. During the muscle repair process PTRF acts as a docking protein, potentially binding MG53 with exposed membrane cholesterol at the injury site. When PTRF is absent in cells, the binding process is interrupted and MG53 can not successfully repair damaged tissues.

* Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to respiratory failure and alpha-1-antitrypsin deficiency, and has symptoms including tremor, fever and angina pectoris. An important gene associated with Pulmonary Disease, Chronic Obstructive is LINC00229 (Long Intergenic Non-Protein Coding RNA 229), and among its related pathways/superpathways are Matrix Metalloproteinases and Rheumatoid arthritis. The drugs Advair and Anoro Ellipta have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotype is chronic obstructive pulmonary disease. A common, complex disorder defined by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease.

* Pulmonary Embolism, also known as pulmonary artery embolism, is related to chronic thromboembolic pulmonary hypertension and respiratory failure, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Pulmonary Embolism is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Lidocaine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system. An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot.

* Pulmonary Emphysema is related to berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification and alpha 1-antitrypsin deficiency, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Pulmonary Emphysema is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Simvastatin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and liver, and related phenotypes are homeostasis/metabolism and hematopoietic system. A long-term, progressive disease of the lungs that primarily causes shortness of breath due to over-inflation of the alveoli (air sacs in the lung). In people with emphysema, the lung tissue involved in exchange of gases (oxygen and carbon dioxide) is impaired or destroyed.

* Pulmonary Fibrosis, Idiopathic, also known as idiopathic pulmonary fibrosis, is related to acute interstitial pneumonia and idiopathic interstitial pneumonia, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Pulmonary Fibrosis, Idiopathic is SFTPA2 (Surfactant Protein A2), and among its related pathways/superpathways are Metabolism of proteins and Rheumatoid arthritis. The drugs Esbriet and Ofev have been mentioned in the context of this disorder. Affiliated tissues include Placenta and Adipose, and related phenotypes are gastroesophageal reflux and pulmonary fibrosis. A condition in which tissues in the lungs become thick and stiff, or scarred, over time. The lungs then lose their ability to move oxygen to the brain and other parts of the body. Common symptoms include shortness of breath and a dry, hacking cough.

* Pulmonary Hypertension, also known as primary pulmonary hypertension, is related to pulmonary venoocclusive disease 1 and antiphospholipid syndrome, and has symptoms including angina pectoris, chest pain and coughing. An important gene associated with Pulmonary Hypertension is BMPR2 (Bone Morphogenetic Protein Receptor Type 2), and among its related pathways/superpathways are Vascular smooth muscle contraction and Human Embryonic Stem Cell Pluripotency. The drugs Adcirca and Adempas have been mentioned in the context of this disorder. Affiliated tissues include Lung, heart and lung, and related phenotypes are cardiovascular system and behavior/neurological. A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling.

* Pulpitis is related to periapical periodontitis and intussusception. An important gene associated with Pulpitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways are EBV LMP1 signaling and LDL Oxidation in Atherogenesis. Affiliated tissues include trigeminal ganglion, testes and bone, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and adipose tissue. Inflammation of dental pulp tissue.

* Pure Autonomic Failure, also known as idiopathic orthostatic hypotension, is related to adenocarcinoma and pleurisy. An important gene associated with Pure Autonomic Failure is DBH (Dopamine Beta-Hydroxylase), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Circadian entrainment. The drugs Midodrine and Droxidopa have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism. A generalized autonomic failure without central nervous system (brain or spinal cord) involvement. the autonomic nervous system is the part of the body that controls involuntary actions, such as the widening or narrowing of the blood vessels. failure of this system can cause a variety of symptoms. the most common symptom of pure autonomic failure is orthostatic hypotension. other symptoms may include decreased sweating, heat intolerance, inability to empty the bladder, erectile dysfunction, incontinence or constipation, and pupil changes.